Research progress of zebrafish used in drug metabolism.
- Author:
Qiu-xia CHEN
1
;
Su ZENG
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cytochrome P-450 Enzyme System;
metabolism;
Embryo, Nonmammalian;
drug effects;
Glucuronosyltransferase;
metabolism;
Inactivation, Metabolic;
Pharmaceutical Preparations;
metabolism;
Polychlorinated Dibenzodioxins;
toxicity;
Receptors, Aryl Hydrocarbon;
metabolism;
Receptors, Cytoplasmic and Nuclear;
metabolism;
Receptors, Steroid;
metabolism;
Teratogens;
toxicity;
Xenobiotics;
metabolism;
Zebrafish;
embryology;
metabolism
- From:
Acta Pharmaceutica Sinica
2011;46(9):1026-1031
- CountryChina
- Language:Chinese
-
Abstract:
Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.
