Synthesis and biological evaluation of sorafenib thiourea derivatives.
- Author:
Zhao YANG
1
;
Zheng FANG
;
Zhi-xiang WANG
;
Ping WEI
Author Information
1. College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemical synthesis;
chemistry;
pharmacology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Humans;
Molecular Structure;
Niacinamide;
analogs & derivatives;
chemical synthesis;
chemistry;
pharmacology;
Phenylurea Compounds;
chemical synthesis;
chemistry;
pharmacology;
Thiourea;
analogs & derivatives;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2011;46(9):1093-1097
- CountryChina
- Language:Chinese
-
Abstract:
Basing on the market multi-target antitumor agent sorafenib, a series of sixteen 4-[4-(2-methyl-aminoacyl-pyridyl)]oxylphenyl aryl thiourea derivatives were designed and synthesized. Their structures were identified by the spectra of 1H NMR, MS and elemental analysis. The evaluation of antitumor bioactivities in vitro was done by MTT method. It was shown that the synthesized compounds had antitumor activities and compounds 1a, 1d, 1i and 1j showed better or equal antitumor activity on sorafenib.
