The mechanical properties and moisture permeability of eudragit L100/S100 free films affected by plasticizers and membrane materials ratio.
- Author:
Guo-song ZHANG
1
;
Chuan-hua FENG
;
Wei JIANG
;
Peng-yi HU
;
Ping DENG
;
Yao ZHANG
;
Xiao-jian LUO
Author Information
1. The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang 330006, China.
- Publication Type:Journal Article
- MeSH:
Citrates;
chemistry;
Humidity;
Hydrogen-Ion Concentration;
Permeability;
Phthalic Acids;
chemistry;
Plasticizers;
chemistry;
Polymethacrylic Acids;
chemistry;
Technology, Pharmaceutical;
methods;
Tensile Strength;
Transition Temperature;
Triacetin;
chemistry
- From:
Acta Pharmaceutica Sinica
2011;46(9):1144-1149
- CountryChina
- Language:Chinese
-
Abstract:
The free membrane of Eudragit L100/S100 which is pH-sensitive, colon-specific was prepared by plane casting films. The film humidity, species and amount of plasticizers, the ratio of membrane material was investigated. The rate of membrane permeability and mechanical properties were used as indicators of orthogonal experiment, and its related properties were studied. The results show that the mechanical properties of the membrane and phragmoid capacity are the best when 30% TEC was used as plasticizer; the ratio of membrane material have little effect on the rate of membrane permeability and mechanical properties. By adjusting the species and amount of plasticizers, the ratio of Eudragit L100/S100, the free membrane which is colon-specific can be obtained.
