Research progress of selective mGluR1 antagonists.
- Author:
Yi-lei YANG
1
;
Wei SUN
;
Cheng PENG
;
Xiao-ye ZHANG
;
Xiao-hong YANG
Author Information
1. Department of Medicinal Chemistry, School of Pharmacy, Jilin University, Changchun 130021, China.
- Publication Type:Journal Article
- MeSH:
Analgesics;
chemical synthesis;
chemistry;
pharmacokinetics;
pharmacology;
Animals;
Benzimidazoles;
chemical synthesis;
chemistry;
pharmacokinetics;
pharmacology;
Blood-Brain Barrier;
Cycloheptanes;
chemical synthesis;
chemistry;
pharmacokinetics;
pharmacology;
Heterocyclic Compounds, 3-Ring;
chemical synthesis;
chemistry;
pharmacokinetics;
pharmacology;
Pain Measurement;
Pyrimidines;
chemical synthesis;
chemistry;
pharmacokinetics;
pharmacology;
Receptors, Metabotropic Glutamate;
antagonists & inhibitors;
chemistry;
Signal Transduction;
drug effects;
Structure-Activity Relationship;
Thiazoles;
chemical synthesis;
chemistry;
pharmacokinetics;
pharmacology
- From:
Acta Pharmaceutica Sinica
2011;46(10):1167-1172
- CountryChina
- Language:Chinese
-
Abstract:
As an important member of metabotropic glutamate receptors (mGluR), metabotropic glutamate receptor 1 (mGluR1) plays an important role in the signal transduction of central nervous system. Selective mGluR1 antagonists can block the signaling pathway activated by mGluR1 and exert a series of physiological actions including analgesia, antianxiety, antidepression, etc. Currently, the discovery and modification of selective mGluR1 antagonists have become a hot research focus. This paper reviews the structural catalogs of selective mGluR1 antagonists and their structure-activity relationships in the last decade.
