Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat.
- Author:
Xiao-yan YU
1
;
Qian-xi CHEN
;
Xiao-yu BAI
;
Shuo TIAN
;
Jia-lin SUN
;
Yang LÜ
;
Guan-hua DU
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Absorption;
Administration, Oral;
Animals;
Area Under Curve;
Calorimetry, Differential Scanning;
Chromatography, High Pressure Liquid;
Crystallization;
Male;
Platelet Aggregation Inhibitors;
administration & dosage;
chemistry;
pharmacokinetics;
Random Allocation;
Rats;
Rats, Wistar;
Spectrophotometry, Infrared;
Ticlopidine;
administration & dosage;
analogs & derivatives;
blood;
chemistry;
pharmacokinetics;
X-Ray Diffraction
- From:
Acta Pharmaceutica Sinica
2011;46(10):1268-1272
- CountryChina
- Language:Chinese
-
Abstract:
Four crystalline forms of clopidogrel bisulfate were characterized by analytical techniques. Aiming to research the absorption characteristics of clopidogrel bisulfate polymorphs after taken orally by rat, and to estimate the influence of crystal form to pharmacodynamic action, four crystalline forms of clopidogrel bisulfate were administered intragastrically to rats, and high performance liquid chromatography (HPLC) was used to measure the contents of clopidogrel bisulfate and its metabolite in rat plasma. The metabolite of clopidogrel bisulfate was detected in rat plasma. There were significant deviations among four crystalline forms in the areas under curve of the metabolite of clopidogrel bisulfate. We concluded that the different crystal forms of clopidogrel bisulfate showed different pharmacokinetic characteristics, which might affect pharmacodynamic action.
