Advances in the study of organic anion transporting polypeptide 1B3.
- Author:
Xue LI
1
;
Yan LI
Author Information
1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Transport;
Cytochrome P-450 CYP3A;
metabolism;
Drug Interactions;
Gene Expression Regulation, Neoplastic;
Gene Frequency;
Hepatocytes;
metabolism;
Humans;
Liver;
metabolism;
Neoplasms;
metabolism;
Organic Anion Transporters, Sodium-Independent;
antagonists & inhibitors;
chemistry;
genetics;
Polymorphism, Single Nucleotide;
RNA, Messenger;
metabolism;
Receptors, Cytoplasmic and Nuclear;
metabolism;
Receptors, Steroid;
metabolism;
Solute Carrier Organic Anion Transporter Family Member 1B3
- From:
Acta Pharmaceutica Sinica
2011;46(11):1279-1285
- CountryChina
- Language:Chinese
-
Abstract:
OATP1B3, a member of SLC superfamily, is specifically expressed on the sinusoidal membrane of hepatocytes and is considered to be important in hepatic drug elimination. The overexpression of OATP1B3 was found recently in tumor tissues such as prostate, colon, and pancreatic tumors. Sequence variations in SLCO1B3 gene, such as SNPs, have been described and a common haplotype consisting of 334T>G and 699G>A SNPs is related to altered transport characteristics of OATP1B3. OATP1B3 is of relevance to drug metabolism through affecting alteration of hepatic concentration of endo- and xenobiotic compounds that interact with nuclear receptors such as PXR and CAR, and thereby directly alter the extent of target gene transcription, including major CYP isoenzymes such as CYP3A4. This review will provide an overview of substrates and inhibitors of OATP1B3 and subsequently to assess the effect of genetic mutation on transport activity. The studies linking OATP1B3 with cancer clinical outcomes are also discussed in this review.
