Recent developments of drug eluting stent coatings.
- Author:
Wen-ping CHEN
1
;
Hong-bing ZHAN
Author Information
1. College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
Drug Carriers;
Drug Delivery Systems;
Drug-Eluting Stents;
Lactic Acid;
Phosphorylcholine;
Polyethylenes;
Polyglycolic Acid;
Prosthesis Design;
Titanium
- From:
Acta Pharmaceutica Sinica
2011;46(11):1301-1307
- CountryChina
- Language:Chinese
-
Abstract:
Drug eluting stents (DESs) have revolutionized the interventional cardiology over the past decade since the first DES became commercially available in Europe in 2002. Compared to bare metal stents that are deployed to keep the vessel open by mechanical force, DESs have an additional function of reducing restenosis by the action of the drug on the target site. Coatings on the stent surface which ensure the maximum delivery of therapeutic agents to the target site with minimal systematic toxicity, also play an important role in adjusting the drug release profile. Coating material and technology not only affect the surface biocompatibility and the integrity maintenance during the implanting process, but also decide the way of drug delivering and transmitting from the coating. This paper reviews the basic principles of DES coating design, the categories of DES coatings, the commonly used clinical DES coatings and their efficiency in reducing restenosis, and finally provides the future perspectives for DES coatings.
