Testicular Cytotoxicity of Intraperitoneal Thio-TEPA in Mice.
- Author:
Ban Whan JUN
1
;
Yong Hyun CHO
Author Information
1. Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
thio-tepa;
testis;
cytotoxicity
- MeSH:
Animals;
Antineoplastic Agents;
Atrophy;
Humans;
Lethal Dose 50;
Male;
Mice*;
Mortality;
Oligospermia;
Testis;
Thiotepa*
- From:Korean Journal of Urology
1988;29(1):9-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mice were used to evaluate the adverse testicular effects of anticancer agents. Testicular cytotoxicity of many chemotherapeutic drugs has been evaluated in mice. In this report, we described thio-TEPA induced testicular toxicity in mature male I. C. R. mice. On day o, mice in the treatment groups were given different single intraperitoneal doses of thio-TEPA(0.1 to 25mg/kg). On day 56, all surviving mice were killed and necropsied. Testicular toxicity was evaluated qualitatively by histology and quantitatively by testicular weight(testis weight/body weight), repopulation index and epididymal index. Progressive dose dependent testicular atrophy and oligospermia occurred at low and intermediate doses of thio-TEPA(0.1 to 5mg/kg). Marked testicular atrophy, oligospermia and germinal aplasia were observed at high dose of thio-TEPA(10mg/kg). LD50 for animal mortality at day 56 for thio-TEPA appears to be 25mg/kg. In this report, we described the quantitative relationship between thio-TEPA dosage and testicular cytotoxicity in mature male I. C. R. mice.
