Histological observations of chemically induced acute hepatic injury repaired by allogeneic bone marrow stem cell transplantation.
- Author:
Sheng-jun LIU
1
;
Chi-hua FANG
;
Xiao-wu CHEN
;
Zhen-xiang RONG
;
Da-jian ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Cells; cytology; Carbon Tetrachloride; toxicity; Chemical and Drug Induced Liver Injury; etiology; pathology; surgery; Hematopoietic Stem Cell Transplantation; methods; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome
- From: Journal of Southern Medical University 2006;26(10):1449-1451
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possibility of repairing chemically induced acute hepatic injuries with allogeneic bone marrow stem cell (BMSC) transplantation.
METHODSA SD rat model of CCl(4)-induced acute hepatic injury was established, which received transplantation of BMSCs (2.0 ml, 1x10(6)/ml) or normal saline injection into the local liver parenchyma, respectively. The rats were sacrificed at 6 h before and 6 h, 1, and 5 weeks after transplantation, and the livers were prepared for microscopic examination.
RESULTSCellular necrosis, bridging necrosis, congestion in the hepatic sinusoid, and inflammatory cell infiltration were seen in the chemically injured livers 6 h after model establishment, and these changes were ameliorated in rats receiving BMSC transplantation.
CONCLUSIONSAllogeneic BMSC transplantation can repair chemically induced acute liver injuries.
