Establishment of rabbit orbital hypertelorism model and evaluation of effects of surgical correction.
- Author:
Qiang YUAN
1
;
Da-lie LIU
;
Ji-long YUAN
;
Lei SHAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Hypertelorism; etiology; surgery; Male; Rabbits; Reconstructive Surgical Procedures; methods; Surgery, Plastic; methods
- From: Journal of Southern Medical University 2006;26(10):1476-1480
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a rabbit model of orbital hypertelorism for plastic and reconstructive surgery and evaluate the surgical effects.
METHODSOrbital osteotomies and medial translocation was performed in 16 New Zealand rabbits (4 to 6 months old) by combined intracranial-extracranial approach. The interorbital distance (IOD) and bone healing between the orbits were evaluated with gross measurement. X-ray and histological examinations were performed immediately and 12 weeks after the operation.
RESULTSThe average IOD of the rabbits was 0.74 cm after completion of the operation, but increased to 0.96 cm 12 weeks after the operation, showing significant relapse of orbital hypertelorism (P<0.01).
CONCLUSIONThe IOD can be decreased successfully in this rabbit model.
