Effects of soy isoflavone on levels of low-grade inflammatory peptides in rats with insulin resistance.
- Author:
Shi-wei CHEN
1
;
Li-shi ZHANG
;
Hong-Min ZHANG
;
Xiao-fan FENG
Author Information
- Publication Type:Journal Article
- MeSH: Adiponectin; blood; Animals; Body Weight; drug effects; C-Reactive Protein; metabolism; Inflammation; blood; physiopathology; Insulin; blood; Insulin Resistance; Interleukin-6; blood; Intra-Abdominal Fat; drug effects; metabolism; Isoflavones; pharmacology; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resistin; blood; Soybeans; chemistry; Tumor Necrosis Factor-alpha; blood
- From: Journal of Southern Medical University 2006;26(10):1484-1486
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of soy isoflavone (SIF) on low-grade inflammation in rats with high-fat diet-induced insulin resistance (IR) and explore the mechanisms of SIF in improving insulin sensitivity.
METHODSThe rats with high-fat diet-induced IR were randomly divided into one model control group and 3 SIF groups gavaged with SIF water solutions at the doses of 50, 150, and 450 mg/kg, respectively. One month after the treatment, fasting blood glucose (FBG), fasting insulin (FINS), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), resistin and adiponectin in the serum were detected by enzymatic method, radioimmunoassay, or enzyme-linked immunosorbent assay.
RESULTSIn the 150 and 450 mg/kg SIF groups, fasting body-weights, visceral adipose tissue deposition, FINS, resistin, TNF-alpha in serum, and IR index were lowered in comparison with the model control group, and in 450 mg/kg SIF group, serum IL-6 level was obviously lowered, and adiponectin increased. No differences were found in serum C-reactive protein levels between the 3 SIF groups.
CONCLUSIONSoy isoflavone may ameliorate insulin sensitivity by decreasing visceral adipose deposition and adjusting low-grade inflammatory molecules derived from white adipose tissue.