Spontaneous discharge modulation by acetylcholine in chronically compressed rat dorsal root ganglion neurons.
- Author:
Hong-Jun YANG
1
;
San-Jue HU
Author Information
- Publication Type:Journal Article
- MeSH: Acetylcholine; pharmacology; Action Potentials; drug effects; Animals; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; physiopathology; Male; Nerve Compression Syndromes; physiopathology; Neurons; drug effects; physiology; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents; pharmacology
- From: Journal of Southern Medical University 2006;26(11):1568-1570
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of acetylcholine (ACh) on spontaneous discharges of compressed rat dorsal root ganglion (DRG) neurons.
METHODSIn chronically compressed DRG model, the spontaneous discharge of a single fiber from the DRG neuron in response to ACh treatment was recorded.
RESULTSActive spontaneous discharges were recorded in the injured DRG, and 77.9% of the injured DRG neurons responded to Ach treatment in the manner of simple excitation, or excitation followed by inhibition. The responses were enhanced with the increase of Ach concentration.
CONCLUSIONInjured DRG remains active in spontaneous discharges, which can be significantly influenced by ACh treatment.
