Serum sCD40L detection for risk evaluation of acute coronary syndromes.
- Author:
Bang-lao XU
1
;
Chun-hua BEI
;
Rong WANG
;
Xiu-xia LEI
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; blood; complications; diagnosis; Aged; Biomarkers; blood; C-Reactive Protein; metabolism; CD40 Ligand; blood; Female; Humans; Male; Middle Aged; Myocardial Infarction; blood; etiology; Predictive Value of Tests; Risk Factors; Troponin I; blood
- From: Journal of Southern Medical University 2006;26(11):1656-1657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the value of serum soluble CD40 ligand (sCD40L) detection in risk evaluation of acute coronary syndromes (ACS).
METHODSThis study involved 200 patients with established diagnosis of ACS, with death or nonfatal myocardial infarction as the end point of observation during the 6-month-long follow-up. Blood samples were obtained from the patients within the initial 72 h of ACS onset, and the levels of sCD40L and C-reactive protein (CRP) were determined with enzyme-linked immunosorbent assay (ELISA). Cardiac troponin I (cTnI) measurement was performed using chemiluminescent immunoassay.
RESULTSOf the 200 patients, 108 had serum sCD40L levels higher than 5.0 microg/L, and the levels of sCD40L, CRP and cTnI were found to significantly correlate with ACS.
CONCLUSIONIndependent detection of serum sCD40L, CRP and cTnI can help predict the risks of ACS, and their combined measurement may increase the sensitivity of the risk prediction and provide new cardiac makers to replace the cardiac enzymes for laboratory diagnosis and risk evaluation of cardiovascular events.
