Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia.
- Author:
Gang WANG
1
;
Shuang-quan ZHANG
;
Hong ZHAN
Author Information
- Publication Type:Journal Article
- MeSH: Acetylcholine; cerebrospinal fluid; Aged; Alkaloids; Anesthesia Recovery Period; Anesthesia, General; Brain; drug effects; metabolism; Cholinesterase Inhibitors; therapeutic use; Cholinesterases; cerebrospinal fluid; Chromatography, High Pressure Liquid; Double-Blind Method; Electrochemistry; Female; Humans; Intraoperative Period; Male; Sesquiterpenes; therapeutic use
- From: Journal of Southern Medical University 2006;26(11):1660-1662
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of huperzine A on cerebral cholinergic system in elderly patients during recovery from general anesthesia.
METHODSThirty elderly patients undergoing elective surgery under general anesthesia were randomized in a double-blind manner into group I (n=15) to receive huperzine A (0.3 mg/2 ml) and group II (n=15) with normal saline (2 ml) given intravenously. Huperzine A or normal saline was administered 30 min before completion of the operation, and acetylcholine (Ach) concentration in the cerebral spinal fluid (CSF) of the patients was determined using high-performance liquid chromatography with electrochemical detector (HPLC-ECD) and the activity of cholinesterase inhibitors (ChE) evaluated with automatic biochemistry analyzer before general anesthesia induction (T1) and 5 h after operation completion (T2).
RESULTSIn both the groups, Ach concentration in the CSF were lower at T2 than that at T1 (P<0.01), and at T2, CSF Ach concentration was significantly higher in group I than in group II (P<0.01); in group I, the activity of CSF ChE at T2 was lower than that at T1 (P<0.01), and also lower than at T2 in group II (P<0.01).
CONCLUSIONHuperzine A can inhibit cholinesterase to increase Ach, which has a positive effect on cerebral cholinergic system in elderly patients during recovery from general anesthesia.
