Preparation of porous polylactic-acid/ bone matrix gelatin composite as scaffold materials for bone-tissue engineering.
- Author:
Yu-min ZHANG
1
;
Bao-xing LI
;
Ji LI
;
Hong-qiang MA
;
Ya-ping ZHAO
;
Lin YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biocompatible Materials; chemistry; Bone Matrix; chemistry; Bone Substitutes; chemistry; Gelatin; chemistry; Humans; Lactic Acid; chemistry; Polyesters; Polymers; chemistry; Porosity; Rats; Tissue Engineering; methods; Tissue Scaffolds
- From: Journal of Southern Medical University 2006;26(12):1745-1748
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop a novel porous poly lactic-acid(PLA)/bone matrix gelatin (BMG) bioactive composite biomaterial with supercritical carbon dioxide (SC-CO2) extraction and determine the optimal proportion of the ingredients by evaluating the physical and chemical characteristics and cellular compatibility of the composites.
METHODSThe PLA/BMG composite biomaterials with various PLA/BMG proportions were prepared with SC-CO2 technique and evaluated by macroscopic observation, porosity and mechanical assessment, and scanning electron micrograph (SEM). The optimal proportion of PLA/BMG was determined in conjunction with the results of cellular compatibility evaluation.
RESULTSBMG proportion in BLA/BMG composite biomaterials prepared with SC-CO2 technique was positively associated with the cellular compatibility and porosity, and inversely with the mechanics of the prepared composite. The results showed BMG content of 30% in PLA/BMG composite was optimal.
CONCLUSIONThe composite with PLA and BMG proportion of 7:3 possesses good physical and chemical characteristics and cellular compatibility, suggesting its potential as the bone implant biomaterial and bone-tissue engineering scaffold.
