Detection of plasma cofilin protein for diagnosis of lung cancer.
- Author:
Yuju ZHENG
1
,
2
;
Ye FANG
;
Shaojin LI
;
Bangxi ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Actin Depolymerizing Factors; blood; Adenocarcinoma; blood; diagnosis; pathology; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; blood; diagnosis; pathology; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lung Neoplasms; blood; diagnosis; pathology; Male; Middle Aged; Neoplasm Staging
- From: Journal of Southern Medical University 2013;33(10):1551-1553
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value.
METHODSThe serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay.
RESULTSThe mean serum content of cofilin protein was 0.485∓0.465 ng/ml in patients with lung cancer and 0.203∓0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744∓0.584 ng/ml, significantly higher than that in stage II patients (0.257∓0.126 ng/ml).
CONCLUSIONSerum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.
