Association of G-894T and T-786C polymorphisms of endothelial nitric oxide synthase gene with sporadic intracranial aneurysms.
- Author:
Li LIU
1
;
Xusheng HUANG
;
Yiling CAI
;
Juan DU
;
Kai FENG
;
Haojun LU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Gene Frequency; Genotype; Humans; Intracranial Aneurysm; genetics; Nitric Oxide Synthase Type III; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
- From: Journal of Southern Medical University 2013;33(12):1733-1737
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between 2 polymorphic loci (G-894T and T-786C) of endothelial nitric oxide synthase (eNOS) gene and sporadic intracranial aneurysms.
METHODSTwo eNOS gene polymorphisms at G-894T and T-786C were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. The genotype and allele frequencies were calculated for the patients and the control group and the association between the gene polymorphisms and the size of aneurysms was analyzed.
RESULTSSignificant differences were found in the genotype distribution for eNOS G-894T polymorphism between the patient and control groups. The GG genotype was associated with a higher risk of intracranial aneurysm than GT+TT genotype (OR:1.897, 95%CI: 1.023-3.519, P=0.04). The patients with intracranial aneurysms had a significantly higher eNOS T-786C C allele frequency than the control group. The C allele was associated with a higher risk of intracranial aneurysm than T allele (OR: 2.116, 95%CI: 1.073-4.151, P=0.030). No significant association was found between the eNOS polymorphisms and the size of aneurysms.
CONCLUSIONeNOS gene may be involved in the occurrence and development of intracranial aneurysms.
