Physical and chemical characteristics of a new cefazolin sodium hydrate crystal.
- Author:
Chang-Qin HU
1
;
Li-Hui YIN
;
Ya-Ning LIANG
Author Information
1. National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China. hucq@nicpbp.org.cn
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
chemistry;
Cefazolin;
chemistry;
Crystallization;
Crystallography, X-Ray;
Drug Stability;
Molecular Conformation;
Molecular Structure;
Sodium;
analysis;
Spectrophotometry, Atomic;
Water;
chemistry
- From:
Acta Pharmaceutica Sinica
2008;43(8):868-872
- CountryChina
- Language:Chinese
-
Abstract:
One kind of new cefazolin sodium hydrate crystal was obtained in the isopropyl alcohol - water system. There are two symmetry independent molecules in the asymmetric unit, both being well ordered in the lattice, and ten independent water positions but generally four to six (mean five) water molecules and one sodium ion present in the unit cell structure. Huge solvent tunnels can be found. Again there are two general regions of water molecules, those in the large solvent tunnels and those in proximity of the sodium ion and the tetrazole moieties of the drug molecule. The physical and chemical characteristics of the new cefazolin sodium hydrate crystal are similar to that of the alpha-form cefazolin sodium crystal, and the new crystal has better chemical stability than amorphous cefazolin sodium powder.
