Significant role of poloxamer in drug transport across blood-brain barrier.
- Author:
Wei ZHANG
1
;
Xiao-ling FANG
Author Information
1. School of Pharmacy, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
ATP Binding Cassette Transporter, Sub-Family B;
antagonists & inhibitors;
metabolism;
ATP Binding Cassette Transporter, Sub-Family G, Member 2;
ATP-Binding Cassette Transporters;
antagonists & inhibitors;
metabolism;
Animals;
Blood-Brain Barrier;
drug effects;
metabolism;
Brain;
metabolism;
Drug Carriers;
Drug Delivery Systems;
Excipients;
pharmacology;
Glucose Transport Proteins, Facilitative;
antagonists & inhibitors;
metabolism;
Humans;
Monocarboxylic Acid Transporters;
antagonists & inhibitors;
metabolism;
Multidrug Resistance-Associated Proteins;
antagonists & inhibitors;
metabolism;
Nanoparticles;
Permeability;
Poloxamer;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2008;43(9):890-897
- CountryChina
- Language:Chinese
-
Abstract:
Poloxamers are found to be an efficient adjuvant with multiple effects and are applied generally in pharmaceutical field. In recent years, it is investigated that poloxamers can increase the permeability of a broad spectrum of drugs through blood-brain barrier (BBB) by means of manifold mechanisms included: (1) inhibiting P-glycoprotein and multidrug-resistance associated protein efflux systems on BBB; (2) adsorbing different apolipoproteins in plasma on the surface of poloxamer-coated nanoparticles, which could interact with BBB through different receptors and mechanisms; (3) connecting to specific ligands and monoclonal antibodies to cross the BBB via specific endogenous transporters localized within the brain capillary endothelium. Significant roles of poloxamer in drug transport across BBB are considered in this review which provides for important guidance to the design of brain-targeted drug delivery system.
