Characterization of microstructure of ibuprofen-hydroxypropyl-beta-cyclodextrin and ibuprofen-beta-cyclodextrin by atomic force microscope.
- Author:
Li-juan WANG
1
;
Zhao-jing ZHU
;
Ke-ke CHE
;
Feng-ge JU
Author Information
1. School of Pharmacy, Chongqing University of Medical Sciences, Chongqing 400016, China.
- Publication Type:Journal Article
- MeSH:
2-Hydroxypropyl-beta-cyclodextrin;
Analgesics, Non-Narcotic;
administration & dosage;
chemistry;
Drug Delivery Systems;
Ibuprofen;
administration & dosage;
chemistry;
Microscopy, Atomic Force;
methods;
Spectrophotometry, Infrared;
X-Ray Diffraction;
beta-Cyclodextrins;
chemistry
- From:
Acta Pharmaceutica Sinica
2008;43(9):969-973
- CountryChina
- Language:Chinese
-
Abstract:
The microstructures of ibuprofen-hydroxypropyl-bets-cyclodextrin (IBU-HP-beta-CyD) and ibuprofen-beta-cyclodextrin (IBU-beta-CyD) were observed by atomic force microscope (AFM). The high resolving capability of AFM has the tungsten filament probe with the spring constant of 0.06 N x m(-1). Samples were observed in a small scale scanning area of 10.5 nm x 10.5 nm and 800 x 800 pixels. The original scanning images were gained by tapping mode at room temperature. Their three-dimensional reconstruction of microstructure was performed by G3DR software. The outer diameters of HP-beta-CyD and beta-CyD are 1.53 nm. The benzene diameter of IBU is 0.62 nm, fitting to the inner diameters of HP-beta-CyD and beta-CyD. The benzene and hydrophobic chain of IBU enter into the hole of cyclodextrin at 1:1 ratio. The results were evidenced by IR, X-ray diffraction and the phase solubility.
