Advances in the chemical and biological studies of polyamides.
- Author:
Shao-Long ZHU
1
;
Ping-Hui GAO
;
Peng LI
;
Yuan-Ying JIANG
;
Da-Zhi ZHANG
Author Information
1. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Base Pairing;
DNA;
chemistry;
genetics;
DNA Footprinting;
Gene Expression Regulation;
drug effects;
Imidazoles;
chemical synthesis;
chemistry;
metabolism;
pharmacology;
Nylons;
chemical synthesis;
chemistry;
metabolism;
pharmacology;
Pyrroles;
chemical synthesis;
chemistry;
metabolism;
pharmacology
- From:
Acta Pharmaceutica Sinica
2008;43(11):1089-1093
- CountryChina
- Language:Chinese
-
Abstract:
Polyamides, containing N-methylpyrrole (Py) and N-methyl-imidazole (Im) amino acids, are synthetic oligomers programmed to read the DNA double helix in the minor groove with high affinities and sequence specificities resulting in modulation of gene expression. They are cell permeable, stable and have no cytotoxicity, which provide a promising tool of gene regulation. We describe here recent advances in the field of DNA binding polyamides, including pairing rules, specifities and affinities to DNA, synthesis methods, cellular and nuclear uptake properties, gene regulation and effectiveness in vivo. The potential problems and difficulties in future research are also discussed.
