The action of TSG101 on HIV-1 budding and related inhibitors.
- Author:
Hong-fei CHEN
1
;
Xin-yong LIU
Author Information
1. Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Anti-HIV Agents;
chemical synthesis;
chemistry;
pharmacology;
DNA-Binding Proteins;
antagonists & inhibitors;
chemistry;
metabolism;
Drug Design;
Endosomal Sorting Complexes Required for Transport;
antagonists & inhibitors;
chemistry;
metabolism;
HIV-1;
growth & development;
physiology;
Transcription Factors;
antagonists & inhibitors;
chemistry;
metabolism;
Virus Replication;
gag Gene Products, Human Immunodeficiency Virus;
metabolism
- From:
Acta Pharmaceutica Sinica
2008;43(12):1165-1170
- CountryChina
- Language:Chinese
-
Abstract:
tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101. So TSG101 would be a useful target for anti-HIV drug design. Now there is already some research on anti-HIV agents based on TSG101 structure. In this article the structure and function of TSG101 as well as the related inhibitors were reviewed.
