Drug discovery based on classic natural products.
- Author:
Li-hong HU
1
;
Ji-qing XU
Author Information
1. Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. simmhulh@mail.shcnc.ac.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-HIV Agents;
chemical synthesis;
pharmacology;
Antineoplastic Agents, Phytogenic;
chemical synthesis;
pharmacology;
Berberine;
analogs & derivatives;
chemical synthesis;
pharmacology;
Biological Products;
chemical synthesis;
chemistry;
pharmacology;
Camptothecin;
analogs & derivatives;
chemical synthesis;
pharmacology;
Drug Discovery;
Humans;
Hypoglycemic Agents;
chemical synthesis;
pharmacology;
Oleanolic Acid;
analogs & derivatives;
chemical synthesis;
pharmacology;
Triterpenes;
chemical synthesis;
pharmacology;
Vinblastine;
analogs & derivatives;
chemical synthesis;
pharmacology
- From:
Acta Pharmaceutica Sinica
2009;44(1):11-18
- CountryChina
- Language:Chinese
-
Abstract:
We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property. The strategy includes: to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry.
