Folate receptor-mediated antitumor drugs.
- Author:
Jie ZHAO
1
;
Sheng-Li CAO
;
Xiao-Lin ZHENG
;
Bo ZHAO
Author Information
1. Department of Chemistry, Capital Normal University, Beijing 100048, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
administration & dosage;
chemistry;
pharmacology;
Carrier Proteins;
metabolism;
Cell Line, Tumor;
Drug Carriers;
Drug Delivery Systems;
Folate Receptors, GPI-Anchored;
Folic Acid;
administration & dosage;
analogs & derivatives;
chemistry;
pharmacology;
Humans;
Neoplasms;
metabolism;
pathology;
Receptors, Cell Surface;
metabolism
- From:
Acta Pharmaceutica Sinica
2009;44(2):109-114
- CountryChina
- Language:Chinese
-
Abstract:
Folate receptor (FR) is over-expressed in a variety of human cancers and it is seldom expressed or found in normal tissues. Therefore, folate receptor-mediated antitumor drugs can be targeted specially to the FR-positive tumor cells. This strategy improves the selectivity of drugs which may destroy the normal tissues in traditional chemotherapeutics. This review provides the delivery mechanism of FR-mediated antitumor drugs and highlights the novel folate-drug conjugates and their activities.
