Effect of arginine vasopressin on alveolar fluid clearance in rats with acute lung injury.
- Author:
Wang DENG
1
;
Daoxin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Lung Injury; drug therapy; Animals; Arginine Vasopressin; pharmacology; Epithelial Sodium Channels; metabolism; Lung; drug effects; pathology; Pulmonary Alveoli; drug effects; physiopathology; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; metabolism
- From: Journal of Southern Medical University 2015;35(11):1602-1605
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of arginine vasopressin (AVP) on alveolar fluid clearance (AFC) in acute lung injury (ALI).
METHODSForty-eight healthy adult Sprague-Dawley rats were randomly divided into control group, ALI model group and AVP treatment group. The pathological changes in the lungs, lung water content, alveolar permeability and AFC were observed, and the expressions of alveolar epithelial sodium channel (ENaC) and Na⁺, K⁺-ATPase were measured.
RESULTSCompared with those in the model group, the rats treated with AVP showed significantly decreased alveolar permeability (0.27 ± 0.15 vs 0.59 ± 0.19) and lung water content (5.01 ± 1.59 vs 8.67 ± 1.79) (P<0.05) and increased AFC (23.56 ± 4.51 vs 8.28 ± 3.57) and of α-ENaC expressions (1.296 ± 0.322 vs 0.349 ± 0.141) and α1-Na⁺, K⁺-ATPase (1.421 ± 0.389 vs 0.338 ± 0.186) (P<0.05).
CONCLUSIONAVP can promote AFC in with ALI possibly by up-regulation of α-ENaC, α1-Na⁺, and K⁺-ATPase.
