Long-term Efficacy and Safety of Risperidone in Patients with Schizophrenia.
- Author:
Chang Yoon KIM
1
;
Chee Hong PARK
Author Information
1. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- Publication Type:Comparative Study ; Review ; Clinical Trial
- Keywords:
Schizophrenia;
Risperidone;
Long-term;
Efficacy;
Safety
- MeSH:
Antipsychotic Agents;
Humans;
Movement Disorders;
Recurrence;
Risperidone*;
Schizophrenia*
- From:Korean Journal of Psychopharmacology
2003;14(Suppl):58-69
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Most informations on the efficacy and safety of new antipsychotic durgs are based on short-term clinical trials. Short-term studies are usually conducted as well-controlled, randomized, comparative studies. However, they do not provide any informations about delayed efficacy or late-onset adverse events such as tardive dyskinesia, functional recovery, relapse or recur rates and maintenance treatment. This is why there is growing interest in long-term clinical studies of antipsychotic drugs. The number of well designed long-term studies, however, are limited compared to that of short-term studies because of practical reasons as well as some methodological issues. In this article, the authors reviewed original research papers on the long-term treatment outcomes of risperidone while discussing the methodological considerations.
