Clinical characteristies and distribution of hepatitis B virus genotype and sub-genotype.
- Author:
Hong ZHAO
1
;
Jun LI
;
Xing-feng LI
;
Chong-wen SI
;
Min YU
;
Wei-bo GONG
;
Yan-yan YU
;
Gui-qiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; China; Female; Genotype; Hepatitis B; physiopathology; virology; Hepatitis B virus; classification; genetics; immunology; isolation & purification; physiology; Humans; Liver; immunology; physiopathology; virology; Male; Middle Aged; Molecular Sequence Data; Viral Load; Young Adult
- From: Chinese Journal of Epidemiology 2007;28(1):74-77
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the distribution and virologic characteristics of HBV genotypes, sub-type and possible association with the severity of liver disease.
METHODS884 patients infected with HBV were enrolled from 8 provinces in China. HBV genotype and sub-type was determined, using PCR-RFLP method.
RESULTSThe most common HBV genotypes were B (20.77% ) and C (78.22 % ) but only 1 patient showed genotypes D. We found sub-type Ba in patients with genotype B, C1 and C2 sub-type in patients with genotype C. Genotype C (83.62%) and sub-type C2 (90.32%) were predominant in northern China. Patients with genotype B were much younger than those with genotype C. There was no significant difference between patients with sub-type C1 and C2. There was no significant difference in liver function and serum HBV-DNA load between patients with genotype B and C,or between patients with sub type C1 and C2. However, hepatic inflammation and fibrosis score in patients with genotype B were significantly lower than those with genotype C.
CONCLUSIONThere were no significantly differences in liver function and HBV-DNA load between patients with genotype B and C, or between patients with sub-type C1 and C2. Hepatic inflammation and fibrosis score in patients with genotype B were significantly lower than those with genotype C. Genotype C/sub-type C2 were preponderance in northern China.
