Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer.
- Author:
Cun-zhi HAN
1
;
Jing SHI
;
Li-li DU
;
Jie-xian JING
;
Xian-wen ZHAO
;
Bao-guo TIAN
;
Fu-guo TIAN
;
Xiu-ying LIU
;
Zhong-shu ZHANG
;
Jin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; blood; genetics; Enzyme-Linked Immunosorbent Assay; Female; Genetic Predisposition to Disease; Humans; Leptin; blood; Lipids; blood; Polymorphism, Genetic; Receptors, Leptin; genetics; Risk
- From: Chinese Journal of Epidemiology 2007;28(2):136-140
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer.
METHODSLEPR G1n223Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 94 patients with breast cancer and 128 healthy controls. The level of leptin were analyzed by enzyme linked immunosorbent assay.
RESULTSIn univariate regression analyses, we found serum level of leptin and LEPR Gin223Arg genotype polymorphism were significantly higrer than those of the controls (P < 0.05-0.001, respectively). Through multivariable analyses, we found that increased risk estimates for breast cancer were among those with leptin level (OR = 1.53, 95% CI: 1.13-2.07, P = 0.006), LEPR Gin223Arg genotype (OR = 4.87, 95%CI:1.30-18.22, P = 0.019), WHR (OR = 3.68, 95% CI: 1.34-10.11, P = 0.011).
CONCLUSIONResults from this study suggested that LEPR Gln233Agr polymorphism, the elevated WHR and serum level of leptin might be correlated with increased risk of breast cancer.
