Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B virus infection among 12 cities in China.
- Author:
Jun-wei GAO
1
;
Ya-juan LI
;
Hui ZHUANG
;
Jie LI
;
Jia WANG
;
Qing-ming DONG
;
Ya-jie CHEN
;
Jun-qi NIU
;
Wei-Min MA
;
Wei ZHAO
;
Bao-an ZHAO
;
Jin-qun ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Genotype; Geography; Hepatitis B virus; genetics; Hepatitis B, Chronic; epidemiology; Humans; Polymerase Chain Reaction
- From: Chinese Journal of Epidemiology 2007;28(4):315-318
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of hepatitis B virus (HBV) genotypes in patients with chronic HBV infection among 11 cities of China.
METHODSA total of 1214 serum samples from patients with chronic HBV infection were collected in 11 cities of China, including Beijing, Qingyuan, Shenzhen, Shijiazhuang, Hanchuan, Nanjing, Changchun, Liaocheng, Jinan, Ningbo and Wenzhou. Genotypes of the 1214 HBV strains were identified by PCR method with type specific primers. Parts of the results were confirmed by direct sequencing analysis of PCR products.
RESULTSAmong the 1214 patients with chronic HBV infection, 0.7% (9/1214)were genotype A, 28.4% (345/1214)genotype B, 58.4% (709/1214) genotype C, and 12.4% (151/1214) genotype B and genotype C mixed infection. No other genotypes were found. Genotype C was predominant in the northern part of China, such as Changchun, Beijing, Shijiazhuang,while genotype B was more commonly seen in south of China. 71.4% (20/28) for patients from Qingyuan and 63.6% (70/110) from Shenzhen were infected with genotype B.
CONCLUSIONHBV genotypes had distinct geographic distribution. Genotype B and C the predominant strains in patients with chronic HBV infection in China. Genotype C was predominantly identified in the northern part of China versus genotype B the south.
