Study on the association between STK15 Phe31Ile polymorphisms and esophageal squamous cell carcinoma.
- Author:
Na WANG
1
;
Gui-ying WANG
;
Wei GUO
;
Xiu-juan DONG
;
Yan LI
Author Information
- Publication Type:Journal Article
- MeSH: Aurora Kinase A; Aurora Kinases; Carcinoma, Squamous Cell; genetics; Case-Control Studies; Esophageal Neoplasms; genetics; Genetic Predisposition to Disease; Genotype; Humans; Polymorphism, Single Nucleotide; Protein-Serine-Threonine Kinases; genetics
- From: Chinese Journal of Epidemiology 2007;28(4):394-397
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relation between single nucleotide polymorphism(SNP) at the 91T-->A(Phe31Ile) position of the STK15 gene and the susceptibility of esophageal squamous cell carcinoma (ESCC) in She county--a ESCC high incidence region in North China.
METHODSPolymerase-chain reaction(PCR)-restriction fragment length polymorphism (RFLP) analysis was used to detect the genotypes of STKl5 Phe31Ile(91T-->A) SNP, and the samples came from 296 ESCC patients and 302 healthy controls.
RESULTSThe risk of ESCC significantly increased in the group which had been smoking or having a family history of upper gastrointestinal cancer (UGIC) (the OR = 1.68 and 1.77, 95% CI: 1.34-2.10 and 1.44-2.19, respectively). Rates of the three genotypes (Phe/Phe, Phe/Ile, Ile/Ile) of the STK15 Phe31Ile (91T-->A) SNPs in ESCC patients were 11.5%, 34.8% and 53.7%, respectively, and were not significantly different from that in the healthy group (11.9%, 36.8% and 51.3%) (chi2 = 0.35, P = 0.84). When compared to Phe/Phe genotype, Phe/Ile and Ile/Ile of STK15 91T-->A(Phe31Ile)did not show effect on the risk of ESCC according to the odds ratio results which were 0.98 (95% CI: 0.57-1.69) and 1.09 (0.65-1.82) respectively. STK15 91T-->A (Phe31Ile) SNP also did not significantly influence on the development of ESCC even the samples were stratified by sex, smoking status and family history of upper gastrointestinal cancer.
CONCLUSIONThe STK15 Phe31Ile(91T-->A) polymorphisms seemed irrelevant with the risk of ESCC in She county.