Association between gene polymorphisms and myocardial infarction in Han Chinese of Yunnan province.
- VernacularTitle:云南汉族心肌梗死相关基因的多态性研究
- Author:
Lin QI
1
;
Jian-mei LI
;
Hao SUN
;
Xiao-qin HUANG
;
Ke-qin LIN
;
Jia-you CHU
;
Zhao-qing YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; China; Factor VII; genetics; Factor XII; genetics; Female; Fibrinogen; genetics; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Myocardial Infarction; genetics; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2012;29(4):413-419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine frequencies of genetic polymorphisms of coagulation factor VII (FVII), coagulation factor FXII (FXII), fibrinogen (FBG) and 9p21 in ethnic Han Chinese from Yunnan province, and to assess the association between such polymorphisms and onset of myocardial infarction (MI).
METHODSOne hundred and forty-two patients with MI and 192 healthy controls were analyzed. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and pyrosequencing were used to determine the genotypes of FVII, FXII, FBG and 9p21.
RESULTSNo significant difference was found in the frequencies of R353Q, 5'F7, C46T, -148C/T, rs1333049 and rs4977574 loci between the two groups (P> 0.05). However, the frequencies of AA of -455G/A, T and TT of rs1333040, T and TT of rs10116277 and G and GG of rs2383207 were significantly higher in MI group compared with the controls (P< 0.05), whilst the frequencies of CT of rs1333040 and GT of rs10116277 were significantly lower in MI group compared with the controls (P<0.05).
CONCLUSIONPolymorphisms of FVII, FXII, -148C/T of FBG and rs1333049 of 9p21 were not associated with myocardial infarction. Polymorphisms of -455G/A of FBG and rs1333040, rs10116277 and rs2383207 of 9p21 may be associated with MI in ethnic Han Chinese from Yunnan province.
