Applications and prospect of multiple displacement amplification in preimplantation genetic diagnosis.
10.3760/cma.j.issn.1003-9406.2012.04.011
- VernacularTitle:多重置换扩增在植入前遗传学诊断中的应用及展望
- Author:
Yin-feng ZHANG
1
;
Hai-ning LUO
;
Xiao-pei LI
;
Yun-shan ZHANG
Author Information
1. Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, People's Republic of China.
- Publication Type:Journal Article
- MeSH:
Genome, Human;
Humans;
Nucleic Acid Amplification Techniques;
methods;
Polymerase Chain Reaction;
methods;
Preimplantation Diagnosis;
methods
- From:
Chinese Journal of Medical Genetics
2012;29(4):431-434
- CountryChina
- Language:Chinese
-
Abstract:
Multiple displacement amplification (MDA) is a new technology for whole genome amplification (WGA), which can generate large amount of high-quality DNA and features high amplification efficiency and fidelity. MDA combined with conventional PCR techniques has been successfully applied for preimplantation genetic diagnosis, which has broaden latter's clinical applications.
