Association study of NOS1 gene polymorphisms and schizophrenia.
- Author:
Jia WANG
1
;
Xiao-hong MA
;
Bo XIANG
;
Jun-yao WU
;
Ying-cheng WANG
;
Wei DENG
;
Ming-li LI
;
Qiang WANG
;
Zong-ling HE
;
Tao LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Nitric Oxide Synthase Type I; genetics; Polymorphism, Single Nucleotide; Schizophrenia; enzymology; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2012;29(4):459-463
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia.
METHODSTwenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.
RESULTSOne SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease.
CONCLUSIONOur results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
