Association study between age-related macular degeneration and R1210C mutation of CFH gene in Chinese population.
- Author:
Si-kui SHEN
1
;
Xiao-qi LIU
;
Fang LU
;
Zheng-lin YANG
;
Yi SHI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Complement Factor H; genetics; Female; Humans; Macular Degeneration; genetics; Male; Middle Aged; Mutation
- From: Chinese Journal of Medical Genetics 2012;29(5):570-572
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEA R1210C mutation of complement factor H (CFH) gene has been associated with age-related macular degeneration (AMD) in Caucasian population. This study was to verify above association in Han Chinese population.
METHODSThe mutation was detected by direct sequencing in 258 patients with wet AMD and 426 matched controls.
RESULTSThe R1210C mutation has not been identified in either sample.
CONCLUSIONThe R1210C mutation in CFH gene is not associated with AMD in Han Chinese population.
