Association between various rs501120 genotypes and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome.
- Author:
Li-yun ZHANG
1
;
Ya-yun WANG
;
Qin HE
;
Man-hua CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; genetics; Aged; Coronary Artery Disease; genetics; Diabetes Complications; genetics; Disease Progression; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Plaque, Atherosclerotic; genetics
- From: Chinese Journal of Medical Genetics 2012;29(5):592-595
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between single nucleotide polymorphism rs501120 and progress of unstable coronary atherosclerotic plaque in diabetes mellitus complicated with acute coronary syndrome (ACS).
METHODSNine hundred and two patients with diabetes complicated with acute coronary syndrome were enrolled. The genotype of rs501120 was determined with TaqMan-MGB probes. Two hundred and five cases of TT genotype, 205 age-and sex-frequency-matched cases of TC genotype and 205 age- and sex-frequency-matched cases of CC genotype were chosen and followed up for 3 years. Clinical data and re-occurrences of ACS were recorded.
RESULTSPatients with TT genotype had a significantly higher incidence of recurrence of ACS than those with CC genotype (TT vs. CC: OR 1.7, 95%CI 1.1-2.7, P= 0.02). And the significance has remained even after adjusting for conventional risk factors by logistic regression (OR 1.6, 95% CI1.05-3.6, P= 0.03). Patients with TT genotype had a significantly higher incidence of myocardial infarction than those with CC genotype(TT vs. CC: OR 1.9, 95% CI 1.2-3.2, P= 0.007).
CONCLUSIONOur results has suggested an association between the rs501120 polymorphism and progress of unstable coronary atherosclerotic plaque.
