Correlation of recurrent pregnancy loss with sperm parameters and sperm DNA fragmentation.
- VernacularTitle:主要精液参数及精子DNA完整率与不明原因习惯性流产的相关性
- Author:
Ying-jun WANG
1
;
Da-wen LI
;
Wei-li ZHANG
;
Rong-qiu ZHANG
;
Gao-neng WANG
;
Rong-rong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Habitual; etiology; genetics; Adult; DNA Damage; DNA Fragmentation; Female; Humans; Male; Pregnancy; Sperm Motility
- From: Chinese Journal of Medical Genetics 2012;29(5):602-605
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate and compare standard sperm parameters and sperm DNA fragmentation in seminal ejaculates from men whose partners had a history of recurrent pregnancy loss (RPL) and a control group of men who had recently established their fertility.
METHODSSemen samples from 85 patients with a history of RPL and 20 men with proven fertility were analyzed according to World Health Organization guidelines. Sperm DNA fragmentation was detected by sperm chromatin dispersion test (SCD).
RESULTSA significant difference (P< 0.05) was observed in sperm motility but not other parameters between the two groups. The mean number of sperm cells with fragmented DNA, represented as DNA fragmentation index, was significantly increased in the RPL group [(34.99± 14.62)%] compared with controls [(10.82± 4.80)%].
CONCLUSIONThis study has indicated that sperm from men with a history of RPL have a higher incidence of DNA damage and poor motility compared with fertile males.
