Association between GIRK4 gene polymorphisms and insulin resistance in Xinjiang Uygur population.
- Author:
Nan-fang LI
1
;
Yong-an KANG
;
De-lian ZHANG
;
Hong-mei WANG
;
Ju-hong ZHANG
;
Yan-rong HU
;
Jing HONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Case-Control Studies; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Insulin Resistance; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors
- From: Chinese Journal of Medical Genetics 2012;29(6):715-719
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between polymorphisms of protein-activated inwardly rectifying K+ channel (GIRK4) gene and insulin resistance (IR) in Xinjiang Uygur population.
METHODSA cross-sectional epidemiological survey-based case-control study was carried out, for which 1295 subjects (including 324 IR patients and 971 non-IR controls) were randomly selected. Functional region of the GIRK4 gene was sequenced for 48 randomly selected IR patients. Representative variable sites were chosen, with its association with IR assessed in 1295 Uygur subjects.
RESULTSrs11221497 variant was associated with IR in Uygur subjects under 50 years old (P=0.017 in genotype model, P=0.009 in dominant model). Subjects with dominant model of CC genotype have an OR of 1.833 (95%CI: 1.157-2.905) for IR.
CONCLUSIONGIRK4 gene polymorphisms may be associated with IR in Uygur ethnics from Xinjiang. The CC genotype of rs11221497 variant is a risk factor for IR.
