A population genetic study of 22 autosomal loci of single nucleotide polymorphisms.
- Author:
Jian-pin TANG
1
;
Feng-hui JIANG
;
Mei-sen SHI
;
Chuan-chao XU
;
Rui CHEN
;
Xiao-pin LAI
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genetic Load; Genetics, Population; Genotype; Humans; Male; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2012;29(6):720-722
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate polymorphisms and forensic efficiency of 22 non-binary single nucleotide polymorphism (SNP) loci.
METHODSOne hundred ethnic Han Chinese individuals were recruited from Dongguan, Guangdong. The 22 loci were genotyped with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS).
RESULTSNine loci were found with a single allele, 4 loci were found to be biallelic, whilst 9 loci were found to have 3 alleles. For 13 polymorphic loci, the combined discrimination power and power of exclusion were 0.999 98 and 0.9330, respectively. For the 9 non-biallelic loci, the combined discrimination power and power of exclusion were 0.9998 and 0.8956, respectively. For motherless cases, the combined power of exclusion was 0.6405 for 13 polymorphic SNPs and 0.6405 for 9 non-binary SNPs.
CONCLUSIONNon-binary loci have a greater discrimination power and exclusion power per SNP.
