Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi.
- Author:
Jin HUANG
1
;
Liang SUN
;
Ming LIU
;
Lin ZHOU
;
Ze-ping LV
;
Cai-you HU
;
Ze-zhi HUANG
;
Chen-guang ZHENG
;
Lin ZHOU
;
Ze YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; genetics; Base Sequence; Case-Control Studies; China; Female; Gene Frequency; Gene Order; Genetic Association Studies; Genotype; Humans; Longevity; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Sirtuin 1; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2013;30(1):55-59
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between SIRT1 gene polymorphisms and the longevity phenomena in Yongfu region of Guangxi. In this case-control study, 500 individuals from Yongfu region of Guangxi were recruited. The subjects were divided into a longevity group (n=223, average age=93.17 U+00B1 3.08 yr) and a healthy control group (n=277, average age=46.92 U+00B1 17.12 yr). Polymerase chain reaction-high resolution melting curve (PCR-HRM) and DNA sequencing were used to determine the allelic and genotypic frequencies of rs3758391, rs3740051, rs2273773, rs4746720 and rs10997870 polymorphisms of SIRT1 gene in the two groups. The association between above polymorphisms and longevity was assessed.
RESULTSIn the longevity group, CT genotype of the rs4746720 locus was significantly more common than CC and TT genotypes (P=0.000, OR=2.098, 95%CI:1.412-4.117). However, no significant difference was found in the allelic and genotypic frequencies of rs3758391, rs3740051 and rs2273773 between the two groups.
CONCLUSIONThere is an association between rs4746720 of SIRT1 gene and longevity in Yongfu region of Guangxi.
