Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan.
- Author:
Qian LI
1
;
Ke-qin LIN
;
Qin LI
;
Jing WANG
;
Juan YU
;
Liang YU
;
Wei YI
;
Xiao-qin HUANG
;
Jia-you CHU
;
Zhao-qing YANG
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Arthritis, Rheumatoid; genetics; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hydrolases; genetics; Male; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; genetics; Protein-Arginine Deiminases
- From: Chinese Journal of Medical Genetics 2013;30(1):111-115
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between genetic polymorphisms of 7 SNPs in PTPN22 and PADI4 genes and susceptibility to rheumatoid arthritis in Yunnan.
METHODSA case-control study was carried out on 192 patients of rheumatoid arthritis and 288 healthy controls. Genotypes of rs33996649 and 1858 loci within PTPN22 gene, and rs11203366 and rs874881 loci within PADI4 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotypes of rs1635579, rs2428736 and rs2240340 in PADI4 gene were determined with pyrosequencing.
RESULTSThe frequencies of alleles and genotypes of rs2240340 locus in PADI4 gene showed a significant difference between rheumatoid arthritis and controls in Yunnan population (P U+003C 0.05).
CONCLUSIONOur results suggested that rs2240340 in PADI4 gene is associated with susceptibility to rheumatoid arthritis in Yunnan.
