A study of interleukin-10 gene polymorphisms in Miao, Dong and Buyi ethnics of Guizhou.
- Author:
Chan-juan WANG
1
;
Ke-ren SHAN
;
Yan HE
;
Ting ZHANG
;
Yi LI
;
Chang-xue WU
;
Chan ZHANG
;
Zhi-zhong GUAN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; ethnology; genetics; China; ethnology; Gene Frequency; Genetics, Population; Genotype; Humans; Interleukin-10; genetics; Polymorphism, Single Nucleotide; Population Groups; genetics; Promoter Regions, Genetic
- From: Chinese Journal of Medical Genetics 2013;30(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate allelic frequencies of interluekin-10 (IL-10) gene promoter in Miao, Dong and Buyi ethnics of Guizhou.
METHODSTaqMan MGB-based real-time PCR was used to determine the genotypes of IL-10 -819 and IL-10 -592 in 589 Miao, Dong and Buyi ethnics of Guizhou.
RESULTSThe allelic frequency of IL-10 -819 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. Allelic frequencies of IL-10 -592 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. In Miao, Dong and Buyi ethnics, the distributions of genotype frequencies of IL-10 -819 and IL-10 -592 were statistically different from Han ethnics from Guizhou and Taiwan of China as well as South Koreans.
CONCLUSIONThere is a heterogeneity in the frequencies of polymorphisms of IL-10 promoter among different ethnic groups.
