Study on the significance and application of crossover analysis in assessing gene-environmental interaction.
- Author:
Pei-hua WANG
1
;
Hong-bing SHEN
;
Feng CHEN
;
Jin-kou ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Contraceptives, Oral; adverse effects; Cross-Over Studies; Environment; Factor V; genetics; Female; Genetic Markers; Genotype; Humans; Mutation; Risk Factors; Venous Thrombosis; chemically induced; genetics
- From: Chinese Journal of Epidemiology 2005;26(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the significance of crossover analysis in gene-environmental interaction studies.
METHODSThrough elaboration of a case-control study on the increased risk of venous thrombosis in oral-conceptive users who were carriers of factor V Leiden mutation, core information from 2 x 4 crossover table were analyzed and compared with stratified analysis and 'case only' study.
RESULTSDifferent models (additive or multiplicative) in analyzing gene-environmental interaction yielded different results. The result of interaction based on multiplicative model was 1.35 (P > 0.05), compatible with that of stratified analysis and case only study. Calculated by crossover analysis based on additive model, synergy index S(S), attributable proportion of interaction (AP) and relative excess risk of interaction (RERI) appeared to be 3.90, 72.24%, 25.08 (P > 0.05) respectively.
CONCLUSIONCrossover analysis should further be applied in gene-environmental interaction studies.
