Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis.
- Author:
Qiong-hong DUAN
1
;
Zhi-gang WANG
;
Gui-bao ZHU
;
Zu-xun LU
;
Lv-yuan SHI
;
Shao-fa NIE
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Colorectal Neoplasms; blood; epidemiology; Enzyme-Linked Immunosorbent Assay; methods; Insulin-Like Growth Factor Binding Protein 3; blood; Insulin-Like Growth Factor I; metabolism; Radioimmunoassay; Risk Factors
- From: Chinese Journal of Epidemiology 2005;26(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer.
METHODSA meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed.
RESULTSThe pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI: 1.14-2.13) and 0.78 (95% CI: 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively.
CONCLUSIONHigh serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.
