Study on the dynamics of IgG antibody in 311 patients with severe acute respiratory syndrome.
- Author:
Bao-xing FAN
1
;
Li-xin XIE
;
Liang-an CHEN
;
Wei-jun CHEN
;
Jie WEN
;
You-ning LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Antibodies, Viral; blood; Convalescence; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; blood; Male; Middle Aged; SARS Virus; immunology; Severe Acute Respiratory Syndrome; immunology
- From: Chinese Journal of Epidemiology 2005;26(3):194-196
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the level and dynamic change of severe acute respiratory syndrome (SARS)-coronavirus-specific IgG antibody in conavalescent SARS patients, and to provide information for prevention and vaccine development.
METHODSIgG antibody against coronavirus was detected by ELISA in the blood of 311 convalescent SARS patients for every 2 - 4 weeks. Stata 7.0 statistics software was used to analyse the results.
RESULTSIgG antibody was detected positive on each testing of all the convalescent patients and its peak appeared 35 days after recovery. IgG antibody level showed a 35.8% decrease within one year.
CONCLUSIONData showed that all the SARS convalescent patients had generated high level of specific IgG antibody against coronavirus in the early stage of recovery, but the antibody level declined along with the progress of convalescence, suggesting that the detection of the IgG antibody should go on until it disappeared.
