Expression of augmenter of liver regeneration in cryptorchidism spermatogenic cells and its implication.
- Author:
Xuan CHEN
1
;
De-ying ZHANG
;
Xing LIU
;
Guang-hui WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cryptorchidism; metabolism; pathology; Cyclooxygenase 2; metabolism; Disease Models, Animal; Fluorescent Antibody Technique; Germ Cells; metabolism; Immunohistochemistry; Male; Proteins; metabolism; Rats; Rats, Sprague-Dawley
- From: National Journal of Andrology 2007;13(8):700-705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of the augmenter of liver regeneration (ALR) in cryptorchidism spermatogenic cells.
METHODSTwenty cryptorchidism rat models were established by surgery, 10 included as normal controls and anther 10 as sham-surgery controls. The expression of ALR was detected by immunochemistry, the COX II level measured by immunofluorescence and the ferric iron contents assayed by Perls stain.
RESULTSALR expressed intensively in the spermatogonia of the control groups but in a signigicantly diminished manner in the cryptorchidism group. No significant difference was found in the COX II level between any two groups of the same age. Ferric iron content of the PND30 cryptorchids decreased significantly (P < 0.05).
CONCLUSIONALR may play an important role in early spermatogenesis. Metabolism dysfunctions caused by ALR defection might be a crucial mechanism for aspermatogenesis of cryptorchidism.
