Effects of co-administration of growth hormone(GH) and aspirin to women during in vitro fertilization and embryo transfer (IVF-ET) cycles.
- Author:
Qun GUAN
1
;
Hua-gang MA
;
Yan-ying WANG
;
Fang ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aspirin; administration & dosage; Embryo Transfer; Female; Fertilization in Vitro; Growth Hormone; administration & dosage; Humans; Infertility, Female; drug therapy; physiopathology; Oocytes; cytology; drug effects; physiology; Ovulation Induction; Pregnancy; Treatment Outcome
- From: National Journal of Andrology 2007;13(9):798-800
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of the co-administration of growth hormone (GH) and aspirin to women with suboptimal response to GnRHa/FSH hyperstimulation protocol during in vitro fertilization and embryo transfer (IVF-ET) cycles.
METHODSForty cases of poor ovarian response in previous IVF-ET cycles were randomly divided into 2 groups: the studied group of GH and aspirin (n = 20), and the control group without GH or aspirin (n = 20).
RESULTSThe co-administration of GH and aspirin significantly increased the rates of retrieved oocytes (P < 0.01), promoted the maturation of oocytes (P < 0.01) and improve the fertilization rates (P < 0.05). However, there were no statistically differences between the two groups in the number of replaced embryos (P > 0.05) and the pregnancy rate (P > 0.05).
CONCLUSIONThe co-administration of GH and aspirin to poor ovarian responders is effective to increase the rates of retrieved oocytes, promote the maturation of oocytes and improve the fertilization rate in IVF-ET.
