Two ways of constructing concealed penis model in rats: a comparative and analytical study.
- Author:
Wei-Min YU
1
;
Fan CHENG
;
Xiao-Bin ZHANG
;
Xiu-Heng LIU
;
Jie ZHANG
;
Yue XIA
;
Ming-Huan GE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Humans; Male; Penis; abnormalities; surgery; Random Allocation; Rats; Rats, Sprague-Dawley; Urogenital Abnormalities
- From: National Journal of Andrology 2007;13(10):879-882
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a stable rat experimental model of concealed penis for studying the effect of buried penis on the structure and function of the corpus cavernosum.
METHODSNinety male SD rats, aged 2 weeks, were randomly divided into 3 groups (A, B and C) of equal number. Groups A and B underwent surgery with intra-purse suture of the penile root and folding suture of the prepuce, respectively, to bury the penis, while Group C were included as sham operation controls.
RESULTSIn Group A, death resulted in 4 cases from acute post-operative urine retention, failure in burying the penis occurred in 5 cases because of soft tissue ulceration around the urethral orifice and in another 3 due to loose concealment. In Group B, 1 died from deep anesthesia and 2 from acute post-operative urine retention. With the penile development and erection, 7 in Group A and 10 in Group B protruded the penis in different stages. In Group C, 1 died from deep anesthesia. The operations succeeded in all the other rats in Groups A and B, with the success rates of 36.7% and 56.7%, respectively. And the concealment could be relieved any time during the experiment.
CONCLUSIONThe experimental rat model of concealed penis can be successfully established by both intra-purse suture of the penile root and folding suture of the prepuce, which is stable and similar to the natural course of this disorder in human.