Non-Hodgkin's lymphoma of the prostate: a report of 2 cases and review of the literature.
- Author:
Xiao-Jian SHEN
1
;
Xiao-Gang ZHENG
;
Xiao-Jun ZHOU
;
Hang-Bo ZHOU
Author Information
- Publication Type:Case Reports
- MeSH: Aged; Antigens, CD20; analysis; Follow-Up Studies; Humans; Immunohistochemistry; Lymphoma, Non-Hodgkin; drug therapy; metabolism; pathology; Male; Middle Aged; Prognosis; Prostatic Neoplasms; drug therapy; metabolism; pathology
- From: National Journal of Andrology 2007;13(10):895-898
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathological characteristics of primary Non-Hodgkin's Lymphoma (NHL) of the prostate.
METHODSTwo cases of primary NHL of the prostate were studied by analyzing the clinical data, pathological features, prognosis and review of the literature.
RESULTSHE showed that the normal prostatic tissues were replaced by diffuse-type cancer tissues composed of oval or round medium- to large- size lymphoid cells, with vesicular nuclei, fine chromatin, 2-4 membrane-bound nucleoli and scanty cytoplasm, with either amphophilic or basophilic. Immunohistochemistry revealed: CD20 +, CD79a +, CD10 -, CD5 -, CD3 - and CD45 - in Case 1 and CD20+ + +, PSA +/-, CKpan -, Syn -, CgA -, 34betaE12 -, P504S - and CD3 - in Case 2. Case 1 received chemotherapy combined with radiotherapy, relapsed 4 years later and stabilized by repeated chemotherapy. Case 2 experienced no recurrence after treated by chemotherapy.
CONCLUSIONSurgical treatment could be avoided by preoperative pathological diagnosis of primary NHL of the prostate, for which combined chemotherapy should be the first preference.
