Expression of coxsackie B virus-adenovirus receptor in prostate cancer Du145 and LNCaP cell lines and its significance.
- Author:
Yong LUO
1
;
Yong-Guang JIANG
;
Da-Lin HE
;
Lin-Lin ZHANG
;
Zhu HOU
;
Ming-Chuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Blotting, Western; Cell Line, Tumor; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Humans; Male; Neoplasm Metastasis; Prostatic Neoplasms; metabolism; pathology; Receptors, Virus; metabolism
- From: National Journal of Andrology 2007;13(10):899-902
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the expression of Coxsackie B virus-adenovirus receptor (CAR) in two prostate cancer cell lines with different metastatic potentials.
METHODSThe expressions of CAR in two prostate cancer cell lines (Du145 and LNCaP) with different metastatic potentials were detected by Western blotting. The Transwell polycarbonate filter was used to analyze the invasive potency.
RESULTSAs one of the adhesion associated proteins, CAR highly expressed in the LNCaP cell line, which is well known with a low metastatic potential, and lowly expressed in Du145 with a high metastatic potential (P < 0.01). The invasive potency of Du145 was significantly higher than that of LNCaP (P < 0.05).
CONCLUSIONThere was a difference in the metastatic phenotypes of CAR among cell lines with different metastatic potentials. The expressions of CAR proteins may play an important role in repressing the metastasis of prostate cancer.
