Genotype analysis of CYP1A2 IVS4 + 43A/G in patients with prostate cancer.
- Author:
Jing-ping GE
1
;
Wu WEI
;
Xue-jun SHANG
;
Zheng-yu ZHANG
;
Song XU
;
Dong WANG
;
Jian-ping GAO
Author Information
- Publication Type:Journal Article
- MeSH: Cytochrome P-450 CYP1A2; genetics; Gene Frequency; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Prostatic Neoplasms; genetics; pathology
- From: National Journal of Andrology 2007;13(11):1002-1004
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the genotype of the single nucleotide polymorphisms(SNP) of CYP1A2 IVS4 + 43A/G in patients with prostate cancer by TaqMan allelic discrimination.
METHODSTaqMan SNP allelic discrimination was performed with the ABI 7300 system to detect the genotype of CYP1A2 IVS4 + 43A/G in 85 patients with prostate cancer.
RESULTSThe genotypes of CYP1A2 IVS4 + 43A/G in the patients were as follows: AA subtype in 5 cases (5.9%), AG in 33 (38.8%), and GG in 47 (55.3%). Each subtype of CYP1A2 IVS4 + 43A/G was not correlated with the Gleason score of prostate cancer.
CONCLUSIONThere was no significant correlation between SNP of CYP1A2 and the differentiation of prostate cancer.
